Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.88 |
| ▸ | PPARD | Q03181 | 5/20 | 0.88 |
| ▸ | PPARA | Q07869 | 5/20 | 0.88 |
| ▸ | HTR6 | P50406 | 15/20 | 0.73 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | HTR1D | P28221 | 1/20 | 0.60 |
| ▸ | HTR1B | P28222 | 1/20 | 0.60 |
| ▸ | HTR1E | P28566 | 1/20 | 0.60 |
| ▸ | HTR1F | P30939 | 1/20 | 0.60 |
| ▸ | HTR7 | P34969 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indeglitazar SCHEMBL29375502 | 0.94 | PPARG (1.00) | PPARGPPARDPPARAHTR6HTR1A | |
| Indeglitazar SCHEMBL3019199 | 0.94 | PPARG (1.00) | PPARGPPARDPPARAHTR6HTR1A | |
| SCHEMBL4605145 | 0.91 | PPARG (0.94) | PPARGPPARDPPARAHTR6HTR1A | |
| SCHEMBL14605552 | 0.91 | PPARG (0.90) | PPARGPPARDPPARAHTR6HTR1A | |
| SCHEMBL352303 | 0.91 | PPARG (0.90) | PPARGPPARDPPARAHTR6HTR1A | |
| SCHEMBL4605850 | 0.91 | PPARG (0.94) | PPARGPPARDPPARAHTR6HTR1A | |
| SCHEMBL3034510 | 0.90 | PPARG (0.89) | PPARGPPARDPPARAHTR6HTR1A | |
| SCHEMBL3036477 | 0.90 | PPARG (0.84) | PPARGPPARDPPARAHTR6HTR1A | |
| SCHEMBL14606008 | 0.90 | PPARG (0.71) | PPARGPPARDPPARAHTR6HTR1A | |
| SCHEMBL5659494 | 0.90 | PPARG (0.88) | PPARGPPARDPPARAHTR6HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007030559-A2 | 1, 3-DISUBSTITUTED INDOLE DERIVATIVES FOR USE AS PPAR MODULATORS | PLEXXIKON, INC. (US) | 2007-03-15 | — | — | WO | disclosed |