Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 15/20 | 0.58 |
| ▸ | PIM1 | P11309 | 3/20 | 0.55 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | ROS1 | P08922 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | FGR | P09769 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1203600 | 0.83 | FYN (0.59) | FYNPIM1MKNK1NTRK1 | |
| SCHEMBL2951694 | 0.81 | FYN (0.78) | FYNPIM1MKNK1JAK2ABL1 | |
| SCHEMBL1203409 | 0.79 | FYN (0.56) | FYNPIM1NTRK1 | |
| SCHEMBL15688830 | 0.79 | FYN (0.62) | FYNPIM1MKNK1 | |
| SCHEMBL1203735 | 0.78 | FYN (0.52) | FYNPIM1NTRK1 | |
| SCHEMBL2940129 | 0.78 | FYN (0.73) | FYNPIM1MKNK1JAK2ABL1 | |
| SCHEMBL1054209 | 0.78 | FYN (0.76) | FYNPIM1MKNK1JAK2ABL1 | |
| SCHEMBL2940455 | 0.77 | FYN (0.78) | FYNPIM1MKNK1JAK2ABL1 | |
| SCHEMBL2943534 | 0.77 | FYN (0.76) | FYNPIM1MKNK1JAK2ABL1 | |
| SCHEMBL2948785 | 0.77 | FYN (0.76) | FYNPIM1MKNK1JAK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007025540-A2 | SUBSTITUTED IMIDAZO[1,2B]PYRIDAZINES AS KINASE INHIBITORS, THE PRODUCTION THEREOF, AND USE OF THE SAME AS MEDICAMENTS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-03-08 | — | — | WO | disclosed |