Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 5/20 | 0.53 |
| ▸ | PAK4 | O96013 | 4/20 | 0.53 |
| ▸ | IGF1R | P08069 | 8/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14605896 | 0.86 | PAK1 (0.72) | PAK1PAK4IGF1R | |
| SCHEMBL14605902 | 0.78 | IGF1R (0.55) | PAK1PAK4IGF1R | |
| SCHEMBL14605909 | 0.77 | IGF1R (0.49) | PAK1PAK4IGF1R | |
| SCHEMBL14605907 | 0.77 | PAK1 (0.49) | PAK1PAK4IGF1R | |
| SCHEMBL14605939 | 0.77 | PAK1 (0.49) | PAK1PAK4IGF1R | |
| SCHEMBL14605908 | 0.76 | PAK1 (0.46) | PAK1PAK4IGF1R | |
| SCHEMBL14605905 | 0.76 | PAK1 (0.46) | PAK1PAK4IGF1R | |
| SCHEMBL14605958 | 0.76 | PAK1 (0.46) | PAK1PAK4IGF1R | |
| SCHEMBL14605901 | 0.74 | PAK1 (0.48) | PAK1PAK4IGF1RINSR | |
| SCHEMBL14606170 | 0.73 | IGF1R (0.45) | PAK1PAK4IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007023382-A2 | PYRIMIDINE AMINO PYRAZOLE COMPOUNDS, POTENT KINASE INHIBITORS | PFIZER INC. (US) | 2007-03-01 | — | — | WO | disclosed |