Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.65 |
| ▸ | ITK | Q08881 | 1/20 | 0.65 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.65 |
| ▸ | PAK4 | O96013 | 8/20 | 0.52 |
| ▸ | PAK1 | Q13153 | 7/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.45 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14605898 | 0.93 | LCK (0.62) | LCKITKAURKBPAK4PAK1 | |
| SCHEMBL14605948 | 0.89 | LCK (0.68) | LCKITKAURKBPAK4PAK1 | |
| SCHEMBL14605956 | 0.89 | LCK (0.59) | LCKITKAURKBPAK4PAK1 | |
| SCHEMBL14606103 | 0.85 | LCK (0.55) | LCKITKAURKBPAK4PAK1 | |
| SCHEMBL14605964 | 0.85 | LCK (0.55) | LCKITKAURKBPAK4PAK1 | |
| SCHEMBL14606096 | 0.85 | LCK (0.55) | LCKITKAURKBPAK4PAK1 | |
| SCHEMBL14606070 | 0.83 | LCK (0.59) | LCKITKAURKBPAK4PAK1 | |
| SCHEMBL14605963 | 0.83 | LCK (0.59) | LCKITKAURKBPAK4PAK1 | |
| SCHEMBL14606047 | 0.83 | LCK (0.63) | LCKITKAURKBPAK4PAK1 | |
| SCHEMBL14605968 | 0.83 | LCK (0.53) | LCKITKAURKBPAK4PAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007023382-A2 | PYRIMIDINE AMINO PYRAZOLE COMPOUNDS, POTENT KINASE INHIBITORS | PFIZER INC. (US) | 2007-03-01 | — | — | WO | disclosed |