Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 12/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.42 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.42 |
| ▸ | VNN1 | O95497 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13119160 | 0.91 | GSK3B (0.66) | GSK3BCDK2CCNE1 | |
| SCHEMBL14301230 | 0.91 | GSK3B (0.53) | GSK3BCHEK1KDM4EALDH1A1CDK2 | |
| SCHEMBL14418651 | 0.90 | GSK3B (0.55) | GSK3BCHEK1CDK2CCNE1CCNA2 | |
| SCHEMBL14545947 | 0.88 | GSK3B (0.56) | GSK3BCHEK1CDK2CCNE1VNN1 | |
| SCHEMBL14545872 | 0.88 | GSK3B (0.53) | GSK3BCHEK1ALDH1A1CDK2CCNE1 | |
| SCHEMBL14545949 | 0.86 | GSK3B (0.60) | GSK3BCHEK1CDK2CCNE1VNN1 | |
| SCHEMBL14418650 | 0.86 | GSK3B (0.61) | GSK3BCHEK1ALDH1A1CDK2CCNE1 | |
| SCHEMBL14545952 | 0.85 | GSK3B (0.52) | GSK3BCHEK1CDK2CCNE1CCNA2 | |
| SCHEMBL12954408 | 0.85 | GSK3B (0.51) | GSK3BCHEK1CDK2CCNE1MAP3K12 | |
| SCHEMBL13289055 | 0.85 | GSK3B (0.51) | GSK3BCHEK1CDK2CCNE1VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070054906-A1 | Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION | 2007-03-08 | — | — | US | disclosed |
| US-20070037824-A1 | Enzyme inhibitors from pyrazolo[1,5a]pyrimidine as enzyme inhibitors | SCHERING CORPORATION | 2007-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037824-A1 | Enzyme inhibitors from pyrazolo[1,5a]pyrimidine as enzyme inhibitors | CDK2, CDK5, CDKN1A | GSK3B 937/4885CHEK1 77/4885KDM4E 462/4885 |
| US-20070054906-A1 | Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors | CDK2, CDK1, CDKN1A | GSK3B 695/4885CHEK1 60/4885KDM4E 731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.