Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 12/20 | 0.72 |
| ▸ | AURKA | O14965 | 8/20 | 0.69 |
| ▸ | JAK2 | O60674 | 2/20 | 0.65 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.65 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.65 |
| ▸ | KDR | P35968 | 2/20 | 0.65 |
| ▸ | GSK3A | P49840 | 2/20 | 0.65 |
| ▸ | GSK3B | P49841 | 2/20 | 0.65 |
| ▸ | PLK4 | O00444 | 1/20 | 0.65 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.65 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.65 |
| ▸ | INSR | P06213 | 1/20 | 0.65 |
| ▸ | LCK | P06239 | 1/20 | 0.65 |
| ▸ | FYN | P06241 | 1/20 | 0.65 |
| ▸ | CDK1 | P06493 | 1/20 | 0.65 |
| ▸ | FES | P07332 | 1/20 | 0.65 |
| ▸ | CSF1R | P07333 | 1/20 | 0.65 |
| ▸ | LYN | P07948 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30072334 | 0.94 | SYK (0.76) | SYKAURKAJAK2AURKBSTK17A | |
| SCHEMBL4276330 | 0.94 | SYK (0.76) | SYKAURKAJAK2AURKBSTK17A | |
| SCHEMBL14607313 | 0.87 | SYK (0.67) | SYKAURKACDK2 | |
| SCHEMBL14607305 | 0.86 | SYK (0.76) | SYKAURKAJAK2AURKBSTK17A | |
| SCHEMBL654705 | 0.85 | SYK (0.70) | SYKAURKAJAK2AURKBSTK17A | |
| SCHEMBL657089 | 0.84 | SYK (1.00) | SYKAURKAJAK2AURKBSTK17A | |
| SCHEMBL4937858 | 0.83 | SYK (0.97) | SYKAURKAJAK2AURKBSTK17A | |
| Hydrochloric Acid SCHEMBL655563 | 0.83 | SYK (0.97) | SYKAURKAJAK2AURKBSTK17A | |
| SCHEMBL656765 | 0.82 | AURKA (1.00) | SYKAURKAJAK2AURKBSTK17A | |
| Hydrochloric Acid SCHEMBL655562 | 0.81 | SYK (0.94) | SYKAURKAJAK2AURKBSTK17A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007027238-A2 | JAK KINASE INHIBITORS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2007-03-08 | — | — | WO | disclosed |