Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.82 |
| ▸ | ERBB2 | P04626 | 19/20 | 0.82 |
| ▸ | ERBB3 | P21860 | 12/20 | 0.70 |
| ▸ | ERBB4 | Q15303 | 12/20 | 0.70 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.67 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.67 |
| ▸ | LCK | P06239 | 1/20 | 0.67 |
| ▸ | LYN | P07948 | 1/20 | 0.67 |
| ▸ | MET | P08581 | 1/20 | 0.67 |
| ▸ | CSK | P41240 | 1/20 | 0.67 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.67 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.67 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2747183 | 0.91 | EGFR (0.86) | EGFRERBB2ERBB3ERBB4BMPR1B | |
| SCHEMBL986159 | 0.90 | EGFR (1.00) | EGFRERBB2ERBB3ERBB4BMPR1B | |
| SCHEMBL2750018 | 0.90 | EGFR (0.85) | EGFRERBB2ERBB3ERBB4BMPR1B | |
| Hydrochloric Acid SCHEMBL2748254 | 0.90 | EGFR (0.99) | EGFRERBB2ERBB3ERBB4BMPR1B | |
| SCHEMBL2749278 | 0.90 | EGFR (0.99) | EGFRERBB2ERBB3ERBB4BMPR1B | |
| SCHEMBL14607267 | 0.88 | EGFR (0.66) | EGFRERBB2ERBB3ERBB4BMPR1B | |
| SCHEMBL14607264 | 0.88 | EGFR (0.64) | EGFRERBB2ERBB3ERBB4BMPR1B | |
| SCHEMBL4545202 | 0.85 | EGFR (0.90) | EGFRERBB2ERBB3ERBB4BMPR1B | |
| Hydrochloric Acid SCHEMBL2749615 | 0.85 | EGFR (0.89) | EGFRERBB2ERBB3ERBB4BMPR1B | |
| SCHEMBL2747543 | 0.85 | EGFR (0.88) | EGFRERBB2ERBB3ERBB4BMPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1752457-A1 | FUSED HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2007-02-14 | — | — | EP | disclosed |