Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 10/20 | 0.62 |
| ▸ | CDK2 | P24941 | 3/20 | 0.59 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.59 |
| ▸ | CDK9 | P50750 | 2/20 | 0.59 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.59 |
| ▸ | IGF1R | P08069 | 4/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | BLK | P51451 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14607300 | 0.91 | AURKA (0.57) | AURKACDK2CCNT1CDK9CCNE1 | |
| SCHEMBL14607344 | 0.91 | BCL6 (0.59) | AURKACDK2CCNT1CDK9CCNE1 | |
| SCHEMBL14607296 | 0.85 | AURKA (0.61) | AURKACDK2CCNT1CDK9CCNE1 | |
| SCHEMBL14607298 | 0.80 | IGF1R (0.59) | AURKACDK2CCNT1CDK9CCNE1 | |
| SCHEMBL2104075 | 0.80 | BCL6 (0.63) | JAK3 | |
| SCHEMBL14607301 | 0.79 | AURKA (0.52) | AURKACDK2CCNT1CDK9CCNE1 | |
| SCHEMBL2101439 | 0.79 | AURKA (0.48) | AURKACDK2CCNT1CDK9CCNE1 | |
| SCHEMBL2103534 | 0.79 | AURKA (0.73) | AURKACDK2AURKBGSK3AGSK3B | |
| SCHEMBL14607294 | 0.78 | AURKA (0.56) | AURKACDK2CCNT1CDK9CCNE1 | |
| SCHEMBL5261848 | 0.77 | IGF1R (0.74) | AURKACDK2CCNT1CDK9CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007027238-A2 | JAK KINASE INHIBITORS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2007-03-08 | — | — | WO | disclosed |