Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.68 |
| ▸ | APP | P05067 | 3/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14611752 | 1.00 | PDE4B (0.68) | PDE4BAPPCSF1RPDE4APDE4C | |
| SCHEMBL17559322 | 0.90 | PDE4B (0.54) | PDE4BAPPCSF1RPDE4APDE4C | |
| SCHEMBL14611594 | 0.88 | PDE4B (0.52) | PDE4BAPPCSF1RPDE4APDE4C | |
| SCHEMBL14611750 | 0.87 | PDE4B (0.51) | PDE4BAPPCSF1RPDE4APDE4C | |
| SCHEMBL14611749 | 0.87 | PDE4B (0.51) | PDE4BAPPCSF1RPDE4APDE4C | |
| SCHEMBL4538042 | 0.86 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4538071 | 0.86 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5355845 | 0.86 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5354764 | 0.86 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5356507 | 0.85 | PDE4B (0.65) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176229-B2 | Cyclic AMP-specific phosphodiesterase inhibitors | ICOS CORPORATION (US) | 2007-02-13 | — | — | US | disclosed |