Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.49 |
| ▸ | PDE4A | P27815 | 4/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14576431 | 0.92 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL6722417 | 0.92 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL5355952 | 0.92 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL5362999 | 0.87 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5355373 | 0.85 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5355379 | 0.85 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5363470 | 0.85 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5363464 | 0.85 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5363456 | 0.85 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5355370 | 0.85 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DPDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176229-B2 | Cyclic AMP-specific phosphodiesterase inhibitors | ICOS CORPORATION (US) | 2007-02-13 | — | — | US | disclosed |