Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.79 |
| ▸ | HPGD | P15428 | 6/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.79 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.79 |
| ▸ | POLB | P06746 | 2/20 | 0.79 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.79 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.79 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.79 |
| ▸ | CLK2 | P49760 | 1/20 | 0.79 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.79 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5009616 | 0.90 | KDM4E (0.75) | KDM4EHPGDALDH1A1HSD17B10KCNH2 | |
| SCHEMBL16010307 | 0.90 | KDM4E (0.78) | KDM4EHPGDALDH1A1HSD17B10KCNH2 | |
| SCHEMBL16009404 | 0.90 | KDM4E (0.82) | KDM4EHPGDALDH1A1HSD17B10KCNH2 | |
| SCHEMBL15132795 | 0.89 | KDM4E (0.85) | KDM4EHPGDALDH1A1HSD17B10KCNH2 | |
| SCHEMBL16008951 | 0.89 | KDM4E (0.77) | KDM4EHPGDALDH1A1HSD17B10KCNH2 | |
| Gatifloxacin SCHEMBL2224369 | 0.89 | KDM4E (1.00) | KDM4EHPGDALDH1A1HSD17B10KCNH2 | |
| Gatifloxacin SCHEMBL29356306 | 0.89 | KDM4E (1.00) | KDM4EHPGDALDH1A1HSD17B10KCNH2 | |
| Gatifloxacin SCHEMBL22591 | 0.89 | KDM4E (1.00) | KDM4EHPGDALDH1A1HSD17B10KCNH2 | |
| (R)-Gatifloxacin SCHEMBL5670068 | 0.89 | KDM4E (1.00) | KDM4EHPGDALDH1A1HSD17B10KCNH2 | |
| (S)-Gatifloxacin SCHEMBL30910969 | 0.89 | KDM4E (1.00) | KDM4EHPGDALDH1A1HSD17B10KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007017762-A2 | PHOSPHONATED FLUOROQUINOLONES, ANTIBACTERIAL ANALOGS THEREOF, AND METHODS FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS | TARGANTA THERAPEUTICS INC. (CA) | 2007-02-15 | — | — | WO | disclosed |