Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 17/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 16/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1340980 | 0.73 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1 | |
| SCHEMBL1343952 | 0.71 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1 | |
| SCHEMBL14618679 | 0.70 | — | — | |
| SCHEMBL1341149 | 0.62 | HSP90AB1 (0.45) | HSP90AA1HSP90AB1CYP3A4 | |
| SCHEMBL1149708 | 0.62 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1CYP2C19 | |
| SCHEMBL1343450 | 0.62 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1 | |
| SCHEMBL1148670 | 0.61 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1 | |
| SCHEMBL1148685 | 0.61 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1 | |
| SCHEMBL1340826 | 0.61 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1 | |
| SCHEMBL14525262 | 0.61 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007021877-A1 | IMIDAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2007-02-22 | — | — | WO | disclosed |