Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 9/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | PDE6D | O43924 | 1/20 | 0.47 |
| ▸ | PDE6A | P16499 | 1/20 | 0.47 |
| ▸ | PDE6G | P18545 | 1/20 | 0.47 |
| ▸ | PDE6B | P35913 | 1/20 | 0.47 |
| ▸ | PDE6C | P51160 | 1/20 | 0.47 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4989485 | 0.91 | PDE5A (0.68) | PDE5AMAPTSMN1; SMN2KDM4EPDE6D | |
| SCHEMBL4991681 | 0.81 | PDE5A (0.70) | PDE5AMAPTSMN1; SMN2KDM4EPDE6D | |
| SCHEMBL4987622 | 0.81 | PDE5A (0.70) | PDE5AMAPTSMN1; SMN2KDM4EPDE6D | |
| SCHEMBL4986260 | 0.79 | PDE5A (0.68) | PDE5AMAPTSMN1; SMN2KDM4EPDE6D | |
| SCHEMBL7162084 | 0.78 | PDE5A (0.69) | PDE5AMAPTSMN1; SMN2KDM4EPDE6D | |
| SCHEMBL7159439 | 0.78 | PDE5A (0.68) | PDE5AMAPTSMN1; SMN2KDM4EPDE6D | |
| Dimethylamine SCHEMBL4989501 | 0.77 | PDE5A (0.67) | PDE5AMAPTSMN1; SMN2KDM4EPDE6D | |
| SCHEMBL7160506 | 0.76 | PDE5A (0.65) | PDE5AMAPTSMN1; SMN2KDM4EPDE6D | |
| SCHEMBL14533923 | 0.75 | PDE5A (0.80) | PDE5AMAPTSMN1; SMN2KDM4EPDE6D | |
| SCHEMBL10193485 | 0.73 | PDE5A (0.63) | PDE5AMAPTSMN1; SMN2KDM4EPDE6D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7173042-B2 | Quinoline inhibitors of cGMP phosphodiesterase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-06 | — | — | US | disclosed |