Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.48 |
| ▸ | ADCK1 | Q86TW2 | 1/20 | 0.48 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.48 |
| ▸ | MRGPRX1 | Q96LB2 | 3/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.38 |
| ▸ | FLT4 | P35916 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19050658 | 0.97 | CHEK1 (0.46) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL685422 | 0.88 | MAP2K1 (0.61) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL19050690 | 0.87 | MRGPRX1 (0.41) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL19050665 | 0.86 | MAP2K1 (0.48) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL387871 | 0.85 | MAP2K1 (0.58) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL392369 | 0.83 | MAP2K1 (0.47) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL391647 | 0.82 | MRGPRX1 (0.44) | MAP2K1MAP2K2MRGPRX1HRH1KIT | |
| SCHEMBL20385592 | 0.80 | MAP2K1 (0.60) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL19050663 | 0.79 | MAP2K1 (0.65) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL685490 | 0.78 | SMN1; SMN2 (0.46) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170183333-A1 | DERIVATIVES OF N-(ARYLAMINO) SULFONAMIDES AS INHIBITORS OF MEK | ARDEA BIOSCIENCES, INC. (US) | 2017-06-29 | — | — | US | disclosed |
| WO-2007014011-A2 | N-(ARYLAMINO)-SULFONAMIDE INHIBITORS OF MEK | ARDEA BIOSCIENCES, INC. (US) | 2007-02-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170183333-A1 | DERIVATIVES OF N-(ARYLAMINO) SULFONAMIDES AS INHIBITORS OF MEK | BRAF, NRAS, MAP3K2 | MAP2K1 52/4885CHEK1 260/4885MAP2K2 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.