Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 13/20 | 0.62 |
| ▸ | AXL | P30530 | 3/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.44 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14620868 | 0.93 | AAK1 (0.60) | AAK1AXLKITNEK1MAP3K11 | |
| SCHEMBL858010 | 0.89 | AAK1 (0.78) | AAK1AXLKIT | |
| SCHEMBL857745 | 0.82 | AAK1 (0.75) | AAK1AXLKITNEK1 | |
| SCHEMBL856906 | 0.78 | AAK1 (1.00) | AAK1KIT | |
| SCHEMBL878825 | 0.73 | KIT (0.76) | AAK1AXLKITNEK1 | |
| SCHEMBL16720076 | 0.71 | AAK1 (0.51) | AAK1AXL | |
| SCHEMBL1516714 | 0.70 | AXL (0.73) | AAK1AXLKITNEK1 | |
| SCHEMBL1516745 | 0.68 | AAK1 (0.64) | AAK1AXLNEK1 | |
| SCHEMBL3764549 | 0.68 | AAK1 (0.77) | AAK1AXLKITMAP3K11 | |
| SCHEMBL14620778 | 0.67 | BRD4 (0.63) | AXLMAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007002433-A1 | PYRROLO [2, 3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2007-01-04 | — | — | WO | disclosed |