Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.50 |
| ▸ | AXL | P30530 | 4/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.48 |
| ▸ | MELK | Q14680 | 3/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | MARK3 | P27448 | 2/20 | 0.48 |
| ▸ | FLT4 | P35916 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.48 |
| ▸ | CLK2 | P49760 | 2/20 | 0.48 |
| ▸ | GSK3A | P49840 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | BLK | P51451 | 2/20 | 0.48 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL878951 | 0.94 | AAK1 (0.53) | AAK1AXLDYRK1AMELKDYRK3 | |
| SCHEMBL878851 | 0.88 | DYRK1A (0.59) | AAK1AXLDYRK1AMELKDYRK3 | |
| SCHEMBL878852 | 0.86 | TUBB1 (0.54) | AAK1AXLDYRK1AMELKDYRK3 | |
| SCHEMBL878871 | 0.83 | TUBB1 (0.46) | AAK1AXLDYRK1AMELKDYRK3 | |
| SCHEMBL414672 | 0.83 | MAPK13 (0.51) | AAK1AXLDYRK1AMELKDYRK3 | |
| SCHEMBL878838 | 0.81 | FGFR4 (0.49) | AAK1AXLDYRK1AMELKDYRK3 | |
| SCHEMBL415002 | 0.79 | AXL (0.69) | AAK1AXLDYRK1AMELKDYRK3 | |
| SCHEMBL878737 | 0.78 | AAK1 (0.54) | AAK1AXLDYRK1AMELKDYRK3 | |
| SCHEMBL7991246 | 0.78 | FGFR4 (0.55) | DYRK1ANTRK1GSK3AGSK3BLCK | |
| SCHEMBL878764 | 0.77 | DYRK1A (0.48) | AAK1AXLDYRK1AMELKDYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007002433-A1 | PYRROLO [2, 3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2007-01-04 | — | — | WO | disclosed |