Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CIT | O14578 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 3/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | STK4 | Q13043 | 1/20 | 0.38 |
| ▸ | STK3 | Q13188 | 1/20 | 0.38 |
| ▸ | SIK1 | P57059 | 1/20 | 0.38 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.38 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL858952 | 0.89 | FGFR1 (0.63) | FGFR1FGFR4LRRK2MEN1GAA | |
| SCHEMBL857262 | 0.76 | FGFR1 (0.65) | FGFR1FGFR4LRRK2KMT2ADHFR | |
| SCHEMBL857805 | 0.70 | FGFR1 (1.00) | FGFR1FGFR4KMT2ATNIKDHFR | |
| SCHEMBL14620677 | 0.68 | CDC7 (0.43) | LRRK2CDK8STK4STK3 | |
| SCHEMBL16178033 | 0.68 | LRRK2 (1.00) | LRRK2MEN1GAAMAPTRAB9A | |
| SCHEMBL858777 | 0.68 | LRRK2 (0.61) | LRRK2MEN1GAAMAPTRAB9A | |
| SCHEMBL8386463 | 0.67 | LRRK2 (0.49) | FGFR1FGFR4LRRK2MAPTSIK1 | |
| SCHEMBL858280 | 0.66 | FGFR1 (0.66) | FGFR1FGFR4CDK8TNIK | |
| SCHEMBL857635 | 0.66 | LRRK2 (0.59) | LRRK2MEN1GAAMAPTRAB9A | |
| SCHEMBL858237 | 0.66 | LRRK2 (0.56) | FGFR1LRRK2MEN1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007002433-A1 | PYRROLO [2, 3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2007-01-04 | — | — | WO | disclosed |