Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 7/20 | 0.52 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.47 |
| ▸ | FLT3 | P36888 | 9/20 | 0.46 |
| ▸ | KIT | P10721 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12235235 | 0.88 | PTK2 (0.52) | PTK2PTK2BCHEK1FLT3KIT | |
| SCHEMBL12234153 | 0.87 | PTK2 (0.52) | PTK2PTK2BCHEK1FLT3KIT | |
| SCHEMBL12235238 | 0.87 | PTK2 (0.51) | PTK2PTK2BFLT3KITKCNH2 | |
| SCHEMBL14621367 | 0.87 | PTK2 (0.51) | PTK2PTK2BFLT3KITKCNH2 | |
| SCHEMBL2322143 | 0.86 | PTK2 (0.65) | PTK2PTK2BCHEK1FLT3KIT | |
| SCHEMBL2322148 | 0.86 | PTK2 (0.65) | PTK2PTK2BCHEK1FLT3KIT | |
| SCHEMBL10149253 | 0.83 | PTK2 (0.57) | PTK2PTK2BFLT3KITKCNH2 | |
| SCHEMBL2526061 | 0.83 | PTK2 (0.57) | PTK2PTK2BFLT3KITKCNH2 | |
| SCHEMBL579158 | 0.83 | PTK2 (0.57) | PTK2PTK2BFLT3KITKCNH2 | |
| SCHEMBL12235237 | 0.83 | PTK2 (0.55) | PTK2PTK2BFLT3KITKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007003596-A1 | 2,4-DIAMINO-PYRIMIDINES USED AS AURORA INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-01-11 | — | — | WO | disclosed |