Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 2/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
| ▸ | BCL2 | P10415 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3471828 | 0.94 | MAPT (0.55) | MAPTSMN1; SMN2POLBTP53ALDH1A1 | |
| SCHEMBL14624812 | 0.89 | TRPV1 (0.53) | MAPTSMN1; SMN2POLBTP53RXRA | |
| SCHEMBL14624121 | 0.89 | MAPT (0.47) | MAPTSMN1; SMN2POLBTP53ALDH1A1 | |
| SCHEMBL3473522 | 0.87 | MAPT (0.53) | MAPTSMN1; SMN2POLBTP53LMNA | |
| SCHEMBL3471008 | 0.85 | MAPT (0.64) | MAPTSMN1; SMN2POLBTP53RXRA | |
| SCHEMBL14623709 | 0.84 | MAPT (0.56) | MAPTSMN1; SMN2POLBTP53LMNA | |
| SCHEMBL3471277 | 0.84 | MAPT (0.57) | MAPTSMN1; SMN2POLBTP53RXRA | |
| SCHEMBL3472395 | 0.83 | MAPT (0.54) | MAPTSMN1; SMN2POLBTP53RXRA | |
| SCHEMBL3471242 | 0.83 | MAPT (0.59) | MAPTSMN1; SMN2POLBTP53RXRA | |
| SCHEMBL14624076 | 0.83 | MAPT (0.55) | MAPTSMN1; SMN2POLBTP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007002559-A1 | PYRAZOLE BASED LXR MODULATORS | EXELIXIS, INC. (US) | 2007-01-04 | — | — | WO | disclosed |