Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.62 |
| ▸ | MAOB | P27338 | 8/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1462433 | 1.00 | GRM5 (0.62) | GRM5MAOBMAOASCN9AADAMTS4 | |
| SCHEMBL1462369 | 0.77 | GRM5 (0.68) | GRM5MAOBMAOASCN9A | |
| SCHEMBL1462367 | 0.77 | GRM5 (0.68) | GRM5MAOBMAOASCN9A | |
| SCHEMBL6931947 | 0.77 | GRM5 (0.68) | GRM5MAOBMAOASCN9A | |
| SCHEMBL6929948 | 0.77 | GRM5 (0.76) | GRM5MAOBMAOASCN9A | |
| SCHEMBL6929971 | 0.74 | GRM5 (0.69) | GRM5MAOBMAOASCN9A | |
| SCHEMBL6928852 | 0.73 | GRM5 (1.00) | GRM5 | |
| SCHEMBL12398879 | 0.73 | GRM5 (1.00) | GRM5 | |
| SCHEMBL12398869 | 0.73 | GRM5 (1.00) | GRM5 | |
| SCHEMBL27567433 | 0.67 | MAOB (0.66) | GRM5MAOBMAOASCN9ANR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2482657-A1 | O-BENZYL NICOTINAMIDE ANALOGS AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS | Vanderbilt University (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011035324-A1 | O-BENZYL NICOTINAMIDE ANALOGS AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS | VANDERBILT UNIVERSITY (US) | 2011-03-24 | — | — | WO | disclosed |