Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM3 | Q86V86 | 2/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | IDE | P14735 | 1/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 2/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GPR3 | P46089 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3243045 | 0.87 | PIM3 (0.59) | PIM3PIM1ALDH1A1CHEK1ATM | |
| SCHEMBL14624979 | 0.87 | CHEK1 (0.44) | PIM3PIM1ALDH1A1CHEK1KDM4E | |
| SCHEMBL3247782 | 0.82 | KDM4E (0.54) | PIM3PIM1ALDH1A1CHEK1KDM4E | |
| SCHEMBL14624981 | 0.82 | CHEK1 (0.40) | PIM3PIM1ALDH1A1CHEK1KDM4E | |
| SCHEMBL14624980 | 0.82 | CHEK1 (0.40) | PIM3PIM1ALDH1A1CHEK1KDM4E | |
| SCHEMBL3251592 | 0.81 | PBRM1 (0.55) | PIM3PIM1ALDH1A1CHEK1KDM4E | |
| SCHEMBL3245579 | 0.79 | KDM4E (0.44) | PIM3PIM1ALDH1A1CHEK1KDM4E | |
| SCHEMBL14624971 | 0.78 | MEN1 (0.47) | ALDH1A1CHEK1KDM4EMAPTMEN1 | |
| SCHEMBL4761273 | 0.78 | PIM3 (0.50) | PIM3PIM1ALDH1A1CHEK1ATM | |
| SCHEMBL3245695 | 0.78 | PIM3 (0.43) | PIM3PIM1ALDH1A1CHEK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | disclosed |