Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 9/20 | 0.41 |
| ▸ | REN | P00797 | 6/20 | 0.36 |
| ▸ | CTSD | P07339 | 6/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14625533 | 0.85 | BACE1 (0.39) | BACE1BACE2 | |
| SCHEMBL3575846 | 0.85 | BACE1 (0.53) | BACE1BACE2RENCTSD | |
| SCHEMBL8379823 | 0.73 | BACE1 (0.62) | BACE1BACE2CTSD | |
| SCHEMBL14625450 | 0.70 | BACE1 (0.39) | BACE1BACE2 | |
| SCHEMBL3576060 | 0.70 | BACE1 (0.47) | BACE1BACE2RENCTSD | |
| SCHEMBL3578398 | 0.65 | BACE1 (0.68) | BACE1BACE2CTSD | |
| SCHEMBL3582643 | 0.65 | BACE1 (0.49) | BACE1BACE2RENCTSD | |
| SCHEMBL4239036 | 0.64 | BACE1 (1.00) | BACE1BACE2RENCTSDKCNH2 | |
| SCHEMBL13017248 | 0.63 | BACE1 (0.69) | BACE1BACE2RENCTSD | |
| SCHEMBL14625793 | 0.63 | BACE1 (0.36) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007005366-A1 | AMlNO-5-(5-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR β-SECRETASE MODULATION | WYETH (US) | 2007-01-11 | — | — | WO | disclosed |