Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 5/20 | 0.52 |
| ▸ | KDM5A | P29375 | 6/20 | 0.51 |
| ▸ | KDM4A | O75164 | 3/20 | 0.51 |
| ▸ | ING2 | Q9H160 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.45 |
| ▸ | KDM7A | Q6ZMT4 | 2/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TTR | P02766 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 2/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | EYA3 | Q99504 | 2/20 | 0.41 |
| ▸ | DRD1 | P21728 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14625579 | 0.89 | SIRT3 (0.53) | CYP2C19KDM5AKDM4AING2CYP2C9 | |
| SCHEMBL3130995 | 0.87 | KDM5A (0.68) | KDM5AKDM4AING2CYP2C9SIRT3 | |
| SCHEMBL4587559 | 0.87 | KDM5A (0.68) | KDM5AKDM4AING2CYP2C9SIRT3 | |
| SCHEMBL3131006 | 0.87 | KDM5A (0.68) | KDM5AKDM4AING2CYP2C9SIRT3 | |
| SCHEMBL25836156 | 0.84 | SIRT3 (0.56) | CYP2C19KDM5AKDM4AING2CYP2C9 | |
| SCHEMBL14625580 | 0.83 | CYP2C19 (0.67) | CYP2C19CYP2C9SIRT3NR1H4ABCB11 | |
| SCHEMBL25808724 | 0.80 | KDM5A (0.63) | CYP2C19KDM5AKDM4AING2CYP2C9 | |
| SCHEMBL13522220 | 0.80 | ABCB1 (0.63) | CYP2C19KDM5AKDM4AING2CYP2C9 | |
| SCHEMBL4587362 | 0.77 | KDM5A (0.67) | KDM5AKDM4AING2CYP2C9SIRT3 | |
| SCHEMBL4588590 | 0.77 | KDM5A (0.67) | KDM5AKDM4AING2CYP2C9SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007011835-A2 | ANTIARRHYTHMIC PRECURSOR COMPOUNDS, METHODS OF SYNTHESIS AND METHODS OF USE | ARYX THERAPEUTICS, INC. (US) | 2007-01-25 | — | — | WO | disclosed |