Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26667759 | 0.80 | BRD4 (0.50) | CA9CA12CA1CA2BRD4 | |
| SCHEMBL18152883 | 0.79 | BRD4 (0.49) | CA9CA12CA1CA2BRD4 | |
| SCHEMBL27054347 | 0.75 | MAPT (0.40) | CA9CA12CA1CA2KDM4E | |
| SCHEMBL8157650 | 0.73 | BRD4 (0.50) | CA9CA12CA1CA2BRD4 | |
| SCHEMBL9697083 | 0.72 | CA12 (0.44) | CA9CA12CA1CA2KDM4E | |
| SCHEMBL29451286 | 0.71 | CA12 (0.47) | CA9CA12CA1CA2KDM4E | |
| SCHEMBL15680316 | 0.70 | BRD4 (0.41) | CA9CA12CA1CA2BRD4 | |
| SCHEMBL6921365 | 0.69 | BRD4 (0.40) | CA9CA12CA1CA2BRD4 | |
| SCHEMBL188773 | 0.69 | KDM4E (0.43) | KDM4EMAPTRAD52ADRA2CALDH1A1 | |
| SCHEMBL25609811 | 0.68 | CA9 (0.58) | CA9CA12CA1CA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007009681-A1 | 1 , 1-DIOXID0-2 , 3-DIHYDRO-l , 2-BENZISOTHIAZ0L-6-YL-1H-INDAZOL-4-YL-2 , 4-PYRIMIDINEDI AMINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2007-01-25 | — | — | WO | disclosed |