SCHEMBL14625955

SCHEMBL14625955

CO[C@@]1(C)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(-c4ccc(C)nc4)c3)C(=O)O[C@@]23C(C)[C@H]3OC(=O)[C@H](C)C(=O)[C@H](C)[C@H]1O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.73
CYP3A5 P20815 2/20 0.73
CYP3A7 P24462 2/20 0.73
CYP3A43 Q9HB55 2/20 0.73
ABCC4 O15439 1/20 0.73
ABCB11 O95342 1/20 0.73
PTGS1 P23219 1/20 0.73
KCNH2 Q12809 1/20 0.73
SLCO1B3 Q9NPD5 1/20 0.73
SLCO1B1 Q9Y6L6 1/20 0.73
HDAC6 Q9UBN7 11/20 0.45
HDAC8 Q9BY41 11/20 0.45
HDAC1 Q13547 9/20 0.45
HDAC3 O15379 5/20 0.45
HDAC4 P56524 5/20 0.45
HDAC7 Q8WUI4 5/20 0.45
HDAC2 Q92769 5/20 0.45
HDAC10 Q969S8 5/20 0.45
HDAC11 Q96DB2 5/20 0.45
HDAC9 Q9UKV0 5/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14625966 0.95 CYP3A4 (0.72) CYP3A4CYP3A5CYP3A7CYP3A43ABCC4
SCHEMBL14626105 0.94 CYP3A4 (0.71) CYP3A4CYP3A5CYP3A7CYP3A43ABCC4
SCHEMBL14626124 0.94 CYP3A4 (0.71) CYP3A4CYP3A5CYP3A7CYP3A43ABCC4
SCHEMBL14625970 0.94 CYP3A4 (0.71) CYP3A4CYP3A5CYP3A7CYP3A43ABCC4
SCHEMBL14626097 0.94 CYP3A4 (0.71) CYP3A4CYP3A5CYP3A7CYP3A43ABCC4
SCHEMBL14626514 0.94 CYP3A4 (0.71) CYP3A4CYP3A5CYP3A7CYP3A43ABCC4
SCHEMBL14625969 0.93 CYP3A4 (0.71) CYP3A4CYP3A5CYP3A7CYP3A43ABCC4
SCHEMBL14625968 0.93 CYP3A4 (0.69) CYP3A4CYP3A5CYP3A7CYP3A43ABCC4
SCHEMBL14590817 0.91 CYP3A4 (0.88) CYP3A4CYP3A5CYP3A7CYP3A43ABCC4
SCHEMBL14625958 0.90 CYP3A4 (0.69) CYP3A4CYP3A5CYP3A7CYP3A43ABCC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7163924-B2 Ketolide derivatives CHIRON CORPORATION (US) 2007-01-16 US disclosed