Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | HTT | P42858 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.40 |
| ▸ | MEN1 | O00255 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NR1D1 | P20393 | 6/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12598666 | 1.00 | MAPT (0.40) | MAPTHTTKDM4EL3MBTL1POLB | |
| SCHEMBL12208101 | 0.96 | MAPT (0.38) | MAPTHTTKDM4EL3MBTL1POLB | |
| SCHEMBL12208104 | 0.96 | MAPT (0.38) | MAPTHTTKDM4EL3MBTL1POLB | |
| SCHEMBL14626545 | 0.88 | MAPT (0.39) | MAPTHTTKDM4EL3MBTL1POLB | |
| SCHEMBL14626541 | 0.88 | MAPT (0.39) | MAPTHTTKDM4EL3MBTL1POLB | |
| SCHEMBL12208112 | 0.87 | MAPT (0.36) | MAPTHTTKDM4EL3MBTL1POLB | |
| SCHEMBL12208105 | 0.87 | MAPT (0.36) | MAPTHTTKDM4EL3MBTL1POLB | |
| SCHEMBL12598669 | 0.82 | CYP2A6 (0.35) | MAPTHTTKDM4EL3MBTL1POLB | |
| SCHEMBL12208117 | 0.80 | CYP2A6 (0.33) | MAPTHTTKDM4EL3MBTL1POLB | |
| SCHEMBL12207933 | 0.79 | KMT2A (0.42) | MAPTHTTKDM4EL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2336141-B1 | PHOSPHORAMIDATE ALKYLATOR PRODRUGS | THRESHOLD PHARMACEUTICALS INC (US) | 2016-03-30 | — | — | EP | disclosed |
| WO-2007002931-A2 | PHOSPHORAMIDATE ALKYLATOR PRODRUGS | THRESHOLD PHARMACEUTICALS, INC. (US) | 2007-01-04 | — | — | WO | disclosed |