Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 11/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.37 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014167 | 0.85 | MAPK14 (0.57) | MAPK14MAPK8MAPK9MAPK10MAPK11 | |
| SCHEMBL5121344 | 0.85 | MAPK14 (0.46) | MAPK14MAPK8 | |
| SCHEMBL14014073 | 0.85 | MAPK14 (0.56) | MAPK14MAPK8 | |
| SCHEMBL5110207 | 0.78 | MAPK14 (0.59) | MAPK14MAPK8MAPK9MAPK10MAPK11 | |
| SCHEMBL14280047 | 0.78 | MAPK14 (0.39) | MAPK14MAPK8MAPK9MAPK10MAPK11 | |
| SCHEMBL14280045 | 0.77 | FGFR1 (0.42) | MAPK14MAPK8 | |
| SCHEMBL5113908 | 0.76 | MAPK8 (0.53) | MAPK14MAPK8MAPK9MAPK10MAPK11 | |
| SCHEMBL5114115 | 0.76 | MAPK14 (0.48) | MAPK14MAPK8MAPK9MAPK10MAPK11 | |
| SCHEMBL5107331 | 0.76 | MAPK14 (0.58) | MAPK14MAPK8MAPK9MAPK10MAPK11 | |
| SCHEMBL14014098 | 0.75 | MAPK14 (0.70) | MAPK14MAPK8MAPK9MAPK10MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169794-B2 | 6-substituted pyrido-pyrimidines | ROCHE PALO ALTO LLC (US) | 2007-01-30 | — | — | US | disclosed |