Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 18/20 | 0.56 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | TEK | Q02763 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | PRKCB | P05771 | 1/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5485854 | 0.88 | EPHB4 (0.56) | EPHB4AURKA | |
| SCHEMBL5477330 | 0.83 | EPHB4 (0.64) | EPHB4KDRTEKABL1EGFR | |
| SCHEMBL5478329 | 0.83 | EPHB4 (0.56) | EPHB4AURKA | |
| SCHEMBL5482107 | 0.81 | POLB (0.56) | EPHB4AURKASYKBTK | |
| SCHEMBL5484746 | 0.79 | EPHB4 (0.58) | EPHB4AURKA | |
| SCHEMBL5485705 | 0.78 | EPHB4 (0.57) | EPHB4AURKA | |
| SCHEMBL5474112 | 0.78 | EPHB4 (0.61) | EPHB4 | |
| SCHEMBL5488365 | 0.78 | EPHB4 (0.51) | EPHB4AURKA | |
| SCHEMBL6683431 | 0.78 | EPHB4 (0.51) | EPHB4AURKA | |
| SCHEMBL5482732 | 0.78 | EPHB4 (0.52) | EPHB4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7160885-B2 | Certain 6, 8-(heteroaryl or aryl) disubstituted imidazo[1,2-a]pyrazines as modulators of Hsp90 complex activity | CGI PHARMACEUTICALS, INC. (US) | 2007-01-09 | — | — | US | disclosed |