Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16324583 | 0.82 | HTT (0.67) | SMN1; SMN2NPC1RAB9AHSP90AA1HTT | |
| SCHEMBL224315 | 0.82 | NPC1 (0.83) | SMN1; SMN2NPC1RAB9AHSP90AA1HTT | |
| SCHEMBL12536643 | 0.81 | KMT2A (0.55) | SMN1; SMN2NPC1LMNAALDH1A1HPGD | |
| SCHEMBL6091434 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2NPC1RAB9AHSP90AA1HTT | |
| SCHEMBL16366860 | 0.80 | SMN1; SMN2 (0.67) | SMN1; SMN2NPC1RAB9AHSP90AA1HTT | |
| SCHEMBL14474305 | 0.78 | HSP90AA1 (0.60) | SMN1; SMN2NPC1RAB9AHSP90AA1HTT | |
| SCHEMBL12536625 | 0.77 | KMT2A (0.48) | SMN1; SMN2NPC1RAB9AHSP90AA1HTT | |
| SCHEMBL4771241 | 0.77 | SMN1; SMN2 (0.67) | SMN1; SMN2NPC1RAB9AHSP90AA1HTT | |
| SCHEMBL13100252 | 0.76 | NPC1 (0.49) | SMN1; SMN2NPC1RAB9AHTTLMNA | |
| SCHEMBL13100433 | 0.75 | MEN1 (0.54) | NPC1HPGDMEN1CYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1743881-A1 | Phenyl-benzyl-ketones | G.J. Consultants Pty Ltd (AU) | 2007-01-17 | — | — | EP | disclosed |