Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 17/20 | 0.49 |
| ▸ | JAK2 | O60674 | 16/20 | 0.49 |
| ▸ | JAK3 | P52333 | 15/20 | 0.49 |
| ▸ | PDE1A | P54750 | 2/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 3/20 | 0.37 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.37 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2055114 | 1.00 | JAK1 (0.49) | JAK1JAK2JAK3PDE1APDE1B | |
| SCHEMBL2055132 | 0.89 | JAK1 (0.46) | JAK1JAK2JAK3TYK2NUAK1 | |
| SCHEMBL2104864 | 0.83 | JAK1 (0.56) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL2105247 | 0.83 | JAK1 (0.57) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL2105308 | 0.82 | JAK1 (0.51) | JAK1JAK2JAK3TYK2NUAK1 | |
| SCHEMBL2106069 | 0.82 | JAK1 (0.51) | JAK1JAK2JAK3TYK2NUAK1 | |
| SCHEMBL2055096 | 0.82 | JAK1 (0.52) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL2055183 | 0.82 | JAK1 (0.52) | JAK1JAK2JAK3TYK2NUAK1 | |
| SCHEMBL2055081 | 0.82 | JAK1 (0.52) | JAK1JAK2JAK3TYK2NUAK1 | |
| SCHEMBL2055105 | 0.82 | JAK1 (0.51) | JAK1JAK2JAK3PDE1BTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007007919-A2 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-01-18 | — | — | WO | disclosed |