Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.51 |
| ▸ | JAK1 | P23458 | 9/20 | 0.51 |
| ▸ | JAK3 | P52333 | 6/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 4/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | ATR | Q13535 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2055050 | 0.85 | JAK2 (0.72) | JAK2JAK1JAK3HSD11B1 | |
| SCHEMBL2055037 | 0.76 | JAK2 (0.74) | JAK2JAK1JAK3 | |
| SCHEMBL14628891 | 0.74 | JAK1 (0.58) | JAK2JAK1JAK3PIK3CAMTOR | |
| SCHEMBL2055048 | 0.73 | JAK2 (0.77) | JAK2JAK1JAK3 | |
| SCHEMBL14628894 | 0.72 | JAK1 (0.53) | JAK2JAK1JAK3PIK3CAMTOR | |
| SCHEMBL2055049 | 0.70 | JAK2 (0.72) | JAK2JAK1JAK3 | |
| SCHEMBL2055042 | 0.70 | JAK2 (0.72) | JAK2JAK1JAK3 | |
| SCHEMBL2055043 | 0.69 | JAK2 (0.74) | JAK2JAK1JAK3 | |
| SCHEMBL2055044 | 0.69 | JAK2 (0.74) | JAK2JAK1JAK3 | |
| SCHEMBL2055046 | 0.69 | JAK2 (0.73) | JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007007919-A2 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-01-18 | — | — | WO | disclosed |