Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.55 |
| ▸ | JAK3 | P52333 | 20/20 | 0.55 |
| ▸ | JAK1 | P23458 | 18/20 | 0.55 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2054902 | 0.86 | JAK2 (0.55) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL2054903 | 0.86 | JAK2 (0.55) | JAK2JAK3JAK1 | |
| SCHEMBL2054863 | 0.85 | JAK2 (0.54) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL2054899 | 0.84 | JAK2 (0.61) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL2054915 | 0.84 | JAK2 (0.53) | JAK2JAK3JAK1 | |
| SCHEMBL2054927 | 0.84 | JAK2 (0.53) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL2054922 | 0.84 | JAK2 (0.53) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL2054905 | 0.84 | JAK2 (0.53) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL2054884 | 0.82 | JAK2 (0.53) | JAK2JAK3JAK1 | |
| SCHEMBL2054925 | 0.82 | JAK2 (0.53) | JAK2JAK3JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007007919-A2 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-01-18 | — | — | WO | disclosed |