Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.70 |
| ▸ | JAK3 | P52333 | 20/20 | 0.70 |
| ▸ | JAK1 | P23458 | 18/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2054993 | 1.00 | JAK2 (0.70) | JAK2JAK3JAK1 | |
| SCHEMBL2054998 | 0.91 | JAK2 (0.63) | JAK2JAK3JAK1 | |
| SCHEMBL2055030 | 0.88 | JAK2 (0.66) | JAK2JAK3JAK1 | |
| SCHEMBL2054955 | 0.85 | JAK2 (0.72) | JAK2JAK3JAK1 | |
| SCHEMBL2054978 | 0.85 | JAK2 (0.71) | JAK2JAK3JAK1 | |
| SCHEMBL2054987 | 0.84 | JAK2 (0.78) | JAK2JAK3JAK1 | |
| SCHEMBL2055011 | 0.84 | JAK2 (0.65) | JAK2JAK3JAK1 | |
| SCHEMBL2054936 | 0.83 | JAK2 (0.74) | JAK2JAK3JAK1 | |
| SCHEMBL2054982 | 0.83 | JAK2 (0.66) | JAK2JAK3JAK1 | |
| SCHEMBL2054940 | 0.82 | JAK2 (0.75) | JAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007007919-A2 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-01-18 | — | — | WO | disclosed |