Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.57 |
| ▸ | JAK3 | P52333 | 18/20 | 0.57 |
| ▸ | JAK1 | P23458 | 16/20 | 0.57 |
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2055013 | 1.00 | JAK2 (0.57) | JAK2JAK3JAK1TYK2CCR1 | |
| SCHEMBL2054982 | 0.86 | JAK2 (0.66) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL2054944 | 0.82 | JAK2 (0.69) | JAK2JAK3JAK1 | |
| SCHEMBL2054924 | 0.82 | JAK2 (0.73) | JAK2JAK3JAK1 | |
| SCHEMBL2054969 | 0.81 | JAK2 (0.60) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL2054951 | 0.80 | JAK2 (0.66) | JAK2JAK3JAK1 | |
| SCHEMBL2055002 | 0.79 | JAK2 (0.69) | JAK2JAK3JAK1 | |
| SCHEMBL2054976 | 0.79 | JAK2 (0.71) | JAK2JAK3JAK1 | |
| SCHEMBL2055011 | 0.78 | JAK2 (0.65) | JAK2JAK3JAK1 | |
| SCHEMBL2054955 | 0.78 | JAK2 (0.72) | JAK2JAK3JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007007919-A2 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-01-18 | — | — | WO | disclosed |