Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.55 |
| ▸ | TTR | P02766 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | FDPS | P14324 | 1/20 | 0.50 |
| ▸ | NQO1 | P15559 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | TYR | P14679 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | DHODH | Q02127 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3295979 | 0.88 | TTR (0.54) | HDAC4MEF2DTTRAPPPTPN1 | |
| SCHEMBL3295973 | 0.88 | TTR (0.54) | HDAC4MEF2DTTRAPPPTPN1 | |
| SCHEMBL10509071 | 0.86 | TTR (0.53) | TTRAPPPTPN1FDPSNQO1 | |
| SCHEMBL1164636 | 0.86 | TTR (0.53) | HDAC4MEF2DTTRAPPPTPN1 | |
| SCHEMBL31380271 | 0.86 | TTR (0.53) | TTRAPPPTPN1FDPSNQO1 | |
| SCHEMBL10509072 | 0.86 | TTR (0.53) | TTRAPPPTPN1FDPSNQO1 | |
| SCHEMBL3439465 | 0.86 | TTR (0.53) | HDAC4MEF2DTTRAPPPTPN1 | |
| SCHEMBL13754654 | 0.85 | TTR (0.51) | HDAC4MEF2DTTRAPPPTPN1 | |
| SCHEMBL2810114 | 0.85 | TTR (0.51) | TTRAPPPTPN1FDPSNQO1 | |
| Hydrochloric Acid SCHEMBL1164635 | 0.85 | TTR (0.51) | HDAC4MEF2DTTRAPPPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017078927-A1 | ANALOGS OF FEXARAMINE AND METHODS OF MAKING AND USING | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2017-05-11 | — | — | WO | disclosed |
| US-7169936-B2 | Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2007-01-30 | — | — | US | disclosed |