Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 17/20 | 0.58 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.58 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.58 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14632025 | 0.94 | MAP2K1 (0.59) | MAP2K1MAP2K2MAP2K5EIF2AK1CYP2C9 | |
| SCHEMBL14632111 | 0.93 | MAP2K1 (0.58) | MAP2K1MAP2K2MAP2K5EIF2AK1CYP2C9 | |
| SCHEMBL14631973 | 0.91 | MAP2K1 (0.61) | MAP2K1MAP2K2MAP2K5EIF2AK1CYP2C9 | |
| SCHEMBL14632102 | 0.91 | MAP2K1 (0.56) | MAP2K1MAP2K2MAP2K5EIF2AK1CYP2C9 | |
| SCHEMBL14632075 | 0.90 | MAP2K1 (0.47) | MAP2K1MAP2K2MAP2K5EIF2AK1CYP2C9 | |
| SCHEMBL14632108 | 0.86 | MAP2K1 (0.59) | MAP2K1MAP2K2MAP2K5EIF2AK1CYP2C9 | |
| SCHEMBL220941 | 0.86 | MAP2K1 (0.66) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL14632039 | 0.85 | MAP2K1 (0.56) | MAP2K1MAP2K2MAP2K5EIF2AK1CYP2C9 | |
| SCHEMBL14632010 | 0.83 | MAP2K1 (0.47) | MAP2K1MAP2K2MAP2K5EIF2AK1CYP2C9 | |
| SCHEMBL218189 | 0.82 | MAP2K1 (0.65) | MAP2K1MAP2K2MAP2K5EIF2AK1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091941-B1 | MAPK/ERK KINASE INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2013-01-23 | — | — | EP | claimed |