Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 17/20 | 0.46 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.46 |
| ▸ | SMC2 | O95347 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | SMC1A | Q14683 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.46 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.46 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.46 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.38 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14632012 | 0.90 | MAP2K1 (0.45) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL14631994 | 0.89 | MAP2K1 (0.54) | MAP2K1MAP2K2MAP2K5EIF2AK1ABCB11 | |
| SCHEMBL14632081 | 0.89 | MAP2K1 (0.48) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL219751 | 0.85 | MAP2K1 (0.54) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL14632059 | 0.80 | MAP2K1 (0.53) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL14631973 | 0.79 | MAP2K1 (0.61) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL14631996 | 0.78 | MAP2K1 (0.39) | MAP2K1MAP2K2CSNK2A2MAP2K5EIF2AK1 | |
| SCHEMBL14631956 | 0.77 | MAP2K1 (0.48) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL14631993 | 0.77 | MAP2K1 (0.57) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL14632019 | 0.77 | MAP2K1 (0.50) | MAP2K1MAP2K2MAP2K5MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091941-B1 | MAPK/ERK KINASE INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2013-01-23 | — | — | EP | claimed |