Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 4/20 | 0.52 |
| ▸ | PLK1 | P53350 | 2/20 | 0.52 |
| ▸ | CDK4 | P11802 | 11/20 | 0.51 |
| ▸ | CCND1 | P24385 | 11/20 | 0.51 |
| ▸ | CDK2 | P24941 | 6/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.49 |
| ▸ | CDK1 | P06493 | 4/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CCND2 | P30279 | 2/20 | 0.47 |
| ▸ | CCND3 | P30281 | 2/20 | 0.47 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.47 |
| ▸ | MARK3 | P27448 | 1/20 | 0.47 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.47 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.47 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14633244 | 0.90 | WEE1 (0.53) | WEE1PLK1CDK4CCND1CDK2 | |
| SCHEMBL14633141 | 0.89 | WEE1 (0.58) | WEE1PLK1CDK4CCND1ALK | |
| SCHEMBL14633199 | 0.88 | WEE1 (0.52) | WEE1CDK4CCND1CDK2CCNE1 | |
| SCHEMBL14633463 | 0.85 | JAK3 (0.54) | WEE1PLK1CDK4CCND1CDK2 | |
| SCHEMBL14633155 | 0.83 | WEE1 (0.64) | WEE1PLK1FGFR4LCKSRC | |
| SCHEMBL14632814 | 0.83 | CDK4 (0.55) | WEE1PLK1CDK4CCND1CDK2 | |
| SCHEMBL14632987 | 0.83 | WEE1 (0.55) | WEE1PLK1CDK4CCND1CDK2 | |
| SCHEMBL14633394 | 0.82 | WEE1 (0.64) | WEE1PLK1FGFR4LCKSRC | |
| SCHEMBL14632903 | 0.81 | WEE1 (0.51) | WEE1PLK1CDK4CCND1ALK | |
| SCHEMBL14633386 | 0.80 | WEE1 (0.66) | WEE1ALKFGFR4LCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796289-B2 | Pyridazino[4,5-D]pyrimidin-5(6H)-one inhibitors of kinases | ABBVIE INC. (US) | 2014-08-05 | — | — | US | claimed |
| US-20130023523-A1 | PYRIDAZINO[4,5-D]PYRIMIDIN-5(6H)-ONE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2013-01-24 | — | — | US | claimed |
| US-9051327-B2 | Pyridazino[4,5-D]pyrimidin-5(6H)-one inhibitors of kinases | ABBVIE INC. (US) | 2015-06-09 | — | — | US | disclosed |
| US-20140296220-A1 | PYRIDAZINO[4,5-D]PYRIMIDIN-5(6H)-ONE INHIBITORS OF KINASES | ABBVIE INC (US) | 2014-10-02 | — | — | US | disclosed |
| US-8796289-B2 | Pyridazino[4,5-D]pyrimidin-5(6H)-one inhibitors of kinases | ABBVIE INC. (US) | 2014-08-05 | — | — | US | disclosed |
| WO-2013013031-A1 | PYRIDAZINO [4, 5 -D] PYRIMIDIN- (6H) -ONE INHIBITORS OF WEE - 1 KINASE | ABBVIE INC. (US) | 2013-01-24 | — | — | WO | disclosed |
| US-20130023523-A1 | PYRIDAZINO[4,5-D]PYRIMIDIN-5(6H)-ONE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2013-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296220-A1 | PYRIDAZINO[4,5-D]PYRIMIDIN-5(6H)-ONE INHIBITORS OF KINASES | WEE1, WEE2, CDK1 | WEE1 1/4885PLK1 93/4885CDK4 31/4885 |
| US-20130023523-A1 | PYRIDAZINO[4,5-D]PYRIMIDIN-5(6H)-ONE INHIBITORS OF KINASES | WEE1, WEE2, CDK1 | WEE1 1/4885PLK1 93/4885CDK4 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.