Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.37 |
| ▸ | WEE1 | P30291 | 3/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 4/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 4/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | SGK1 | O00141 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2468378 | 0.90 | CDK1 (0.39) | NPC1RAB9AKMT2AFLT3KDR | |
| SCHEMBL2467099 | 0.86 | GRM4 (0.40) | WEE1RIPK2NOD2ACVR1KDR | |
| SCHEMBL14634241 | 0.86 | KDR (0.40) | MEN1NPC1PKMRAB9AKMT2A | |
| SCHEMBL14633720 | 0.84 | CDK2 (0.39) | FLT3KDRALKABCB11SGK1 | |
| SCHEMBL14634243 | 0.83 | SGK1 (0.40) | CHEK1ABCB11SGK1JAK1JAK3 | |
| SCHEMBL14633971 | 0.83 | SGK1 (0.39) | CHEK1FLT3KDRALKABCB11 | |
| SCHEMBL14634281 | 0.83 | CDK1 (0.39) | FLT3KDRALKABCB11SGK1 | |
| SCHEMBL2466308 | 0.82 | GRM4 (0.41) | CHEK1FLT3KDRALKABCB11 | |
| SCHEMBL2472742 | 0.81 | JAK2 (0.40) | FLT3KDRALKABCB11SGK1 | |
| SCHEMBL2468759 | 0.80 | NTRK1 (0.44) | CHEK1FLT3RIPK2KDRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130023534-A1 | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | claimed |
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | claimed |
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | MAP3K19, MAP3K1, MAP3K20 | MEN1 2485/4885NPC1 2912/4885PKM 1088/4885 |
| US-20130023534-A1 | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | CDK2, MAP3K19, MAP3K1 | MEN1 2580/4885NPC1 3580/4885PKM 464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.