Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 2/20 | 0.49 |
| ▸ | CDK9 | P50750 | 3/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | MAP2K4 | P45985 | 4/20 | 0.44 |
| ▸ | MAP2K7 | O14733 | 3/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2471600 | 0.89 | JAK1 (0.47) | EPHB4CDK9CCNT1CDK2CCNE1 | |
| SCHEMBL2469164 | 0.89 | RIPK2 (0.44) | EPHB4CDK9CDK2RIPK2JAK1 | |
| SCHEMBL14634034 | 0.89 | EPHB4 (0.49) | EPHB4CDK9CCNT1CDK2CCNE1 | |
| SCHEMBL14634222 | 0.88 | RIPK2 (0.43) | CDK9CCNT1CDK2CCNE1RIPK2 | |
| SCHEMBL14634112 | 0.86 | GRM4 (0.52) | RIPK2PTGS2MAP2K4MAP2K7LCK | |
| SCHEMBL14634262 | 0.85 | NTRK1 (0.44) | CDK2RIPK2JAK1JAK3MAP2K4 | |
| SCHEMBL14634194 | 0.84 | JAK1 (0.47) | EPHB4CDK9CCNT1CDK2CCNE1 | |
| SCHEMBL14633568 | 0.82 | RIPK2 (0.41) | RIPK2PTGS2MAP2K4MAP2K7LCK | |
| SCHEMBL2472549 | 0.80 | RIPK2 (0.47) | EPHB4CDK9CCNT1CDK2CCNE1 | |
| SCHEMBL14634327 | 0.80 | EPHB4 (0.61) | EPHB4CDK9CCNT1CDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130023534-A1 | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | claimed |
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | claimed |
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | MAP3K19, MAP3K1, MAP3K20 | EPHB4 2462/4885CDK9 55/4885CCNT1 331/4885 |
| US-20130023534-A1 | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | CDK2, MAP3K19, MAP3K1 | EPHB4 1932/4885CDK9 45/4885CCNT1 282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.