Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.57 |
| ▸ | LYN | P07948 | 4/20 | 0.47 |
| ▸ | SYK | P43405 | 4/20 | 0.47 |
| ▸ | TXK | P42681 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 6/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 4/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | PLK4 | O00444 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | FYN | P06241 | 2/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | ROS1 | P08922 | 2/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14650714 | 0.93 | BTK (0.48) | BTKLYNSYKTXKKDR | |
| Hydrochloric Acid SCHEMBL14634848 | 0.90 | BTK (0.47) | BTKLYNSYKTXKKDR | |
| SCHEMBL14650715 | 0.86 | BTK (0.44) | BTKLYNSYKTXKKDR | |
| SCHEMBL14650511 | 0.86 | BTK (0.43) | BTKLYNSYKTXKKDR | |
| Hydrochloric Acid SCHEMBL14635259 | 0.85 | BTK (0.43) | BTKLYNSYKTXKKDR | |
| SCHEMBL14650748 | 0.84 | GRM4 (0.53) | BTKKDRCDK2CDK4CCNE1 | |
| SCHEMBL14650318 | 0.84 | AURKA (0.47) | BTKKDRCDK2JAK3AURKA | |
| Hydrochloric Acid SCHEMBL14634686 | 0.84 | LYN (0.60) | BTKLYNSYKTXKKDR | |
| SCHEMBL2437220 | 0.82 | BTK (0.54) | BTKLYNSYKTXKKDR | |
| SCHEMBL14650590 | 0.81 | CDK2 (0.43) | BTKKDRCDK2CDK4CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130023534-A1 | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023534-A1 | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | CDK2, MAP3K19, MAP3K1 | BTK 302/4885LYN 292/4885SYK 449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.