Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 3/20 | 0.47 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 7/20 | 0.45 |
| ▸ | LYN | P07948 | 2/20 | 0.44 |
| ▸ | TXK | P42681 | 2/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | YES1 | P07947 | 1/20 | 0.44 |
| ▸ | HCK | P08631 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14650757 | 0.87 | TNNI3K (0.49) | TNNI3KSRCNEK1EPHB4LYN | |
| SCHEMBL14650586 | 0.84 | EPHB4 (0.61) | TNNI3KEPHB4LYNTXKSYK | |
| SCHEMBL14650608 | 0.83 | TNNI3K (0.50) | TNNI3KEPHB4LYNTXKSYK | |
| SCHEMBL14634689 | 0.82 | TNNI3K (0.52) | TNNI3KEPHB4LYNTXKSYK | |
| SCHEMBL14650618 | 0.81 | TNNI3K (0.53) | TNNI3KEPHB4LYNTXKSYK | |
| SCHEMBL12334574 | 0.81 | TNNI3K (0.53) | TNNI3KEPHB4LYNTXKSYK | |
| Hydrochloric Acid SCHEMBL14635136 | 0.81 | TNNI3K (0.52) | TNNI3KSRCEPHB4LYNTXK | |
| SCHEMBL14650765 | 0.80 | SYK (0.53) | TNNI3KSRCEPHB4LYNTXK | |
| Hydrochloric Acid SCHEMBL14634865 | 0.79 | SYK (0.52) | TNNI3KSRCEPHB4LYNTXK | |
| SCHEMBL14650772 | 0.79 | TNNI3K (0.50) | TNNI3KSRCEPHB4LYNTXK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130023534-A1 | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | disclosed |
| US-20130023534-A1 | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023534-A1 | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | CDK2, MAP3K19, MAP3K1 | TNNI3K 53/4885SRC 266/4885NEK1 84/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.