Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | TEC | P42680 | 1/20 | 0.41 |
| ▸ | TXK | P42681 | 1/20 | 0.41 |
| ▸ | FRK | P42685 | 1/20 | 0.41 |
| ▸ | BLK | P51451 | 1/20 | 0.41 |
| ▸ | BMX | P51813 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.41 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.41 |
| ▸ | SRMS | Q9H3Y6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15914192 | 1.00 | BTK (0.56) | BTKLCKLYNTECTXK | |
| SCHEMBL14631267 | 0.88 | BTK (0.57) | BTKLCKLYNTECTXK | |
| SCHEMBL14630604 | 0.88 | BTK (0.56) | BTKLCKLYNTECTXK | |
| SCHEMBL14637061 | 0.87 | BTK (0.50) | BTKLCKLYNTECTXK | |
| SCHEMBL14636296 | 0.87 | BTK (0.49) | BTKLCKLYNTECTXK | |
| SCHEMBL15913687 | 0.87 | BTK (0.55) | BTKLCKLYNTECTXK | |
| SCHEMBL14636741 | 0.87 | BTK (0.57) | BTKLCKLYNTECTXK | |
| SCHEMBL14636791 | 0.87 | BTK (0.56) | BTKLCKLYNTECTXK | |
| SCHEMBL15913905 | 0.87 | BTK (0.49) | BTKLCKLYNTECTXK | |
| SCHEMBL14637496 | 0.87 | BTK (0.49) | BTKLCKLYNTECTXK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2734529-A1 | BTK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2014-05-28 | — | — | EP | disclosed |
| WO-2013010380-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-01-24 | — | — | WO | disclosed |