Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.61 |
| ▸ | LCK | P06239 | 2/20 | 0.54 |
| ▸ | LYN | P07948 | 2/20 | 0.54 |
| ▸ | TEC | P42680 | 2/20 | 0.54 |
| ▸ | TXK | P42681 | 2/20 | 0.54 |
| ▸ | FRK | P42685 | 2/20 | 0.54 |
| ▸ | BLK | P51451 | 2/20 | 0.54 |
| ▸ | BMX | P51813 | 2/20 | 0.54 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.54 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.54 |
| ▸ | SRMS | Q9H3Y6 | 2/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | YES1 | P07947 | 1/20 | 0.54 |
| ▸ | FGR | P09769 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | CSK | P41240 | 1/20 | 0.54 |
| ▸ | ITK | Q08881 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14636563 | 1.00 | BTK (0.61) | BTKLCKLYNTECTXK | |
| SCHEMBL14636818 | 0.93 | BTK (0.61) | BTKLCKLYNTECTXK | |
| SCHEMBL14637083 | 0.93 | BTK (0.61) | BTKLCKLYNTECTXK | |
| SCHEMBL14636973 | 0.93 | BTK (0.61) | BTKLCKLYNTECTXK | |
| SCHEMBL15913716 | 0.93 | BTK (0.61) | BTKLCKLYNTECTXK | |
| SCHEMBL14637085 | 0.91 | BTK (0.54) | BTKLCKLYNTECTXK | |
| SCHEMBL14630171 | 0.90 | BTK (0.59) | BTKLCKLYNTECTXK | |
| SCHEMBL14636996 | 0.90 | BTK (0.59) | BTKLCKLYNTECTXK | |
| SCHEMBL15913869 | 0.90 | BTK (0.52) | BTKLCKLYNTECTXK | |
| SCHEMBL14638594 | 0.89 | BTK (0.56) | BTKLCKLYNTECTXK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013010380-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-01-24 | — | — | WO | disclosed |