Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 11/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.60 |
| ▸ | MAPT | P10636 | 10/20 | 0.60 |
| ▸ | BLM | P54132 | 9/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | TSHR | P16473 | 5/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.60 |
| ▸ | RECQL | P46063 | 4/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 4/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.60 |
| ▸ | THPO | P40225 | 2/20 | 0.60 |
| ▸ | ADRB2 | P07550 | 8/20 | 0.58 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30420447 | 1.00 | TDP1 (0.60) | TDP1KDM4EMAPTBLMHSD17B10 | |
| SCHEMBL11141488 | 1.00 | TDP1 (0.60) | TDP1KDM4EMAPTBLMHSD17B10 | |
| SCHEMBL3442523 | 0.83 | TDP1 (0.61) | TDP1KDM4EMAPTBLMHSD17B10 | |
| Norepinephrine SCHEMBL14940777 | 0.80 | BLM (0.79) | TDP1KDM4EMAPTBLMHSD17B10 | |
| SCHEMBL29216358 | 0.80 | KDM4E (0.41) | TDP1KDM4EMAPTBLMHSD17B10 | |
| SCHEMBL3182357 | 0.80 | TSHR (0.67) | TDP1BLMTSHRPMP22NFKB1 | |
| SCHEMBL7245882 | 0.80 | GAA (0.54) | BLMTSHRPMP22NFKB1CYP3A4 | |
| SCHEMBL8289998 | 0.79 | TDP1 (0.54) | TDP1KDM4EMAPTBLMHSD17B10 | |
| SCHEMBL18735793 | 0.79 | BLM (0.46) | TDP1KDM4EMAPTBLMHSD17B10 | |
| SCHEMBL21348210 | 0.79 | FFAR1 (0.51) | TDP1KDM4EMAPTBLMHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007008603-A1 | MONOMETHYLVALINE COMPOUNDS HAVING PHENYLALANINE SIDE-CHAIN MODIFICATIONS AT THE C-TERMINUS | SEATTLE GENETICS, INC. (US) | 2007-01-18 | — | — | WO | disclosed |