Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | MIF | P14174 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12241028 | 0.87 | NPC1 (0.47) | NPC1RAB9AMIFMAPTPOLB | |
| SCHEMBL14641597 | 0.81 | ASAH1 (0.39) | MIFMAPTPOLBMEN1KMT2A | |
| SCHEMBL12241023 | 0.81 | POLB (0.46) | NPC1RAB9AMIFMAPTPOLB | |
| SCHEMBL12241027 | 0.79 | POLB (0.46) | NPC1RAB9AMIFMAPTPOLB | |
| SCHEMBL12241035 | 0.75 | PRKD1 (0.49) | MAPTPOLBTP53 | |
| SCHEMBL12241030 | 0.72 | POLB (0.44) | MIFMAPTPOLBMEN1KMT2A | |
| SCHEMBL12241260 | 0.72 | POLB (0.48) | MIFMAPTPOLBMEN1KMT2A | |
| SCHEMBL2546995 | 0.71 | MAPT (0.49) | MIFMAPTPOLBMEN1KMT2A | |
| SCHEMBL12241020 | 0.69 | POLB (0.42) | MIFMAPTPOLBMEN1KMT2A | |
| SCHEMBL2544326 | 0.68 | POLB (0.46) | MIFMAPTPOLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150551-B1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2013-01-16 | — | — | EP | disclosed |