Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 3/20 | 0.67 |
| ▸ | KIT | P10721 | 15/20 | 0.63 |
| ▸ | FLT3 | P36888 | 11/20 | 0.63 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | INSR | P06213 | 1/20 | 0.60 |
| ▸ | IGF1R | P08069 | 1/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12126998 | 0.92 | NTRK1 (0.67) | NTRK1KITFLT3AURKAINSR | |
| SCHEMBL14642075 | 0.92 | KIT (0.59) | NTRK1KITFLT3AURKAINSR | |
| SCHEMBL1336372 | 0.91 | NTRK1 (0.71) | NTRK1KITFLT3AURKAINSR | |
| SCHEMBL1334247 | 0.87 | NTRK1 (0.70) | NTRK1KITFLT3AURKAINSR | |
| SCHEMBL1335582 | 0.85 | NTRK1 (0.79) | NTRK1KITFLT3AURKAINSR | |
| SCHEMBL12127360 | 0.84 | KIT (0.59) | NTRK1KITFLT3AURKAINSR | |
| SCHEMBL1334861 | 0.84 | KIT (0.87) | NTRK1KITFLT3AURKAINSR | |
| SCHEMBL1336278 | 0.83 | KIT (0.73) | NTRK1KITFLT3AURKAINSR | |
| SCHEMBL1334201 | 0.82 | NTRK1 (0.60) | NTRK1KITFLT3AURKAINSR | |
| SCHEMBL1336567 | 0.82 | NTRK1 (0.60) | NTRK1KITFLT3AURKAINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354399-B2 | Substituted indazole derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-01-15 | — | — | US | disclosed |