Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 20/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7448853 | 0.85 | LRRK2 (0.70) | LRRK2 | |
| SCHEMBL7453776 | 0.77 | LRRK2 (0.77) | LRRK2 | |
| SCHEMBL28261209 | 0.74 | MAPT (0.48) | — | |
| SCHEMBL7452819 | 0.70 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL7446611 | 0.69 | LRRK2 (0.80) | LRRK2 | |
| SCHEMBL15003190 | 0.69 | LRRK2 (0.89) | LRRK2 | |
| SCHEMBL12065527 | 0.68 | LRRK2 (0.81) | LRRK2 | |
| SCHEMBL7456753 | 0.68 | LRRK2 (0.77) | LRRK2 | |
| SCHEMBL16839615 | 0.66 | MAPT (0.44) | — | |
| SCHEMBL12065535 | 0.66 | LRRK2 (0.77) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354420-B2 | Aminopyrimidine derivatives as LRRK2 inhibitors | GENENTECH, INC. (US) | 2013-01-15 | — | — | US | disclosed |