Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.69 |
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 6/20 | 0.57 |
| ▸ | RAB9A | P51151 | 6/20 | 0.57 |
| ▸ | MAOB | P27338 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14615283 | 0.95 | MEN1 (0.68) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL13679558 | 0.92 | MEN1 (0.72) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL13679557 | 0.90 | MEN1 (0.60) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL13679564 | 0.90 | MAPT (0.70) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL13679556 | 0.88 | MAPT (0.68) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL13679566 | 0.88 | MAPT (0.73) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL14615273 | 0.87 | MAPT (0.89) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL14642444 | 0.86 | MAPT (0.70) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL14615301 | 0.86 | MAPT (0.67) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL13679555 | 0.86 | MEN1 (0.67) | MEN1KMT2AMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772275-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |