Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.55 |
| ▸ | CDC25A | P30304 | 4/20 | 0.52 |
| ▸ | CDC25B | P30305 | 1/20 | 0.52 |
| ▸ | NPC1L1 | Q9UHC9 | 6/20 | 0.51 |
| ▸ | USP2 | O75604 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | RORC | P51449 | 3/20 | 0.50 |
| ▸ | RORA | P35398 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GPR183 | P32249 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | OSBP | P22059 | 1/20 | 0.50 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.50 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CDC45 | O75419 | 2/20 | 0.47 |
| ▸ | PTPRC | P08575 | 1/20 | 0.47 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13770759 | 0.74 | NR1H4 (0.54) | NR1H4OSBPOSBP2GPBAR1 | |
| SCHEMBL24425754 | 0.73 | NPC1L1 (0.64) | NR1H4CDC25ACDC25BNPC1L1USP2 | |
| SCHEMBL19116422 | 0.72 | NR1H4 (0.69) | NR1H4USP2LMNAMEN1KMT2A | |
| SCHEMBL20972927 | 0.72 | GPBAR1 (0.72) | CDC25ACDC25BNPC1L1USP2LMNA | |
| SCHEMBL5341067 | 0.72 | GPBAR1 (0.72) | CDC25ACDC25BNPC1L1USP2LMNA | |
| SCHEMBL9951526 | 0.72 | GPBAR1 (0.72) | CDC25ACDC25BNPC1L1USP2LMNA | |
| SCHEMBL21000302 | 0.72 | GPBAR1 (0.72) | CDC25ACDC25BNPC1L1USP2LMNA | |
| SCHEMBL20972926 | 0.72 | GPBAR1 (0.72) | CDC25ACDC25BNPC1L1USP2LMNA | |
| SCHEMBL22472242 | 0.72 | GPBAR1 (0.72) | CDC25ACDC25BNPC1L1USP2LMNA | |
| SCHEMBL19545492 | 0.72 | GPBAR1 (0.72) | CDC25ACDC25BNPC1L1USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8357368-B2 | Methods of treating pancreatic or liver cancer using hedgehog antagonists | CURIS, INC. (US) | 2013-01-22 | — | — | US | disclosed |